• The condition is very severe and the skin area affected is very large. The condition is stopping the person from functioning normally.
• Fever or excessive tiredness.
• Another infection is present that requires antibiotic treatment.
• Tried a treatment and it was unsuccessful.
• Decreased immune system function from medications or health conditions.
• Infection is on the scalp, fingernails, toenails, face, genitals or mucus membranes.
• The affected area is oozing pus.
• Diabetes.